Wegovy (semaglutide) was approved for weight loss as an injection in 2021 and as an oral tablet in June 2026 in the UK. Both routes deliver the same active ingredient but via different administration methods.

How They Work (Same Mechanism)

Both pill and injection are GLP-1 receptor agonists. They suppress appetite, slow stomach emptying, and improve blood sugar control. Efficacy is comparable, but delivery differs.

Bioavailability: Pill vs Injection

Injection (Wegovy): 100% bioavailability. The full dose enters the bloodstream. Predictable effect.

Tablet (Oral Rybelsus/Wegovy): Approximately 1% bioavailability. Requires higher doses (14mg tablet vs 2.4mg injection) because most is broken down by stomach acid and enzymes. Requires specific administration (empty stomach, upright, with water).

Dosing Differences

Because tablets are poorly absorbed, oral doses are much higher. A 14mg oral tablet delivers similar effect to a 2.4mg injection. This is why tablets require strict administration rules.

Administration & Convenience

Injection: Once-weekly (easy to remember). Inject yourself at home or with help. No specific meal timing. Storage in fridge.

Tablet: Daily administration. Must be taken on empty stomach, 30 minutes before food, sitting upright. More complex routine. Higher pill burden.

Cost Comparison

Injection: £99-200/month depending on provider and dose tier

Tablet: Similar pricing (£99-200/month), but requires daily adherence monitoring

Side Effects: Route Differences?

GI side effects (nausea, vomiting) are similar. Injection may cause injection-site reactions. Tablet requires upright posture to prevent esophageal irritation (rare but reported).

Which to Choose

Injection if you prefer weekly dosing, simpler routine, and 100% predictable absorption.

Tablet if you fear needles, prefer daily control, or have logistics challenges with weekly appointments.

The Bottom Line

Both are effective. Choice depends on lifestyle fit, needle anxiety, and compliance preference. Many people trial one, then switch if needed.