UK weight-loss tablet guide
Weight-loss tablets in the UK: compare current options
There is no single “weight-loss tablet”. Wegovy pill, Orlistat, Xenical, Alli and Mysimba have different active ingredients, prescription routes, prices and safety information. This guide helps you compare the current UK options before you look at individual providers.
Start with the medicine, not the marketing
What this page can and cannot answer
Tablet Compare can show current public prices and explain how the routes differ. It cannot decide which medicine is suitable for you. Prescription medicines require a clinical assessment, and a lower listed price does not make two treatments equivalent.
Current UK weight-loss tablet routes
Use the route cards to reach the correct comparison or guide. Rybelsus is covered separately because its UK licence is for type 2 diabetes, not weight management.
Wegovy pill
Oral semaglutide for weight management, supplied through private prescription routes. Compare the named dose, provider status and standard price.
Orlistat, Xenical and Alli
Orlistat is a non-GLP-1 route. Product strength matters: 60mg pharmacy products and 120mg prescription products should not be compared as identical packs.
Mysimba
A prescription prolonged-release tablet containing naltrexone and bupropion. Provider assessment, safety information and ongoing review are part of the route.
How the tablet routes differ
| Route | What it is | UK access context | Useful comparison questions |
|---|---|---|---|
| Wegovy pill | Oral semaglutide for weight management. | Private prescription route. | Is the dose live, what is the standard price, and what does the provider include? |
| Orlistat / Xenical / Alli | A non-GLP-1 medicine that reduces fat absorption. | Product-specific pharmacy or prescription routes. | What strength and pack are listed, and is a pharmacy or prescription route involved? |
| Mysimba | Naltrexone/bupropion prolonged-release tablets. | Prescription-only medicine. | What assessment, review and delivery terms apply alongside the listed price? |
| Rybelsus | Oral semaglutide for type 2 diabetes. | Different licensed role. | Is the question about diabetes care or a weight-management route? Do not treat it as a like-for-like Wegovy pill price. |
Compare like for like before using a price
Check the medicine and strength
A pack, dose or capsule strength can change the meaning of a price. Start with the exact medicine rather than a generic tablet label.
Keep standard prices separate
Comparison tables use standard public prices. Discount codes, subscriptions, bundles and introductory terms belong on offer and provider pages.
Read the provider details
Delivery, consultation and eligibility checks may differ between providers. Use the provider profile before following an external link.
Oral semaglutide and future tablets
Wegovy pill and Rybelsus both involve oral semaglutide but have different UK product roles. Our dedicated guide to semaglutide tablets covers the two routes, dose ladders and current status in detail. Future names such as Foundayo/orforglipron and a possible oral tirzepatide route should remain watchlist topics until there is a real UK authorisation and regulated supply route.
Sources
MHRA: Wegovy pill approval · NHS: Orlistat · eMC: Xenical product information · eMC: Mysimba product information
Information only. A prescriber or pharmacist can advise on medicine-specific suitability, safety and use.
Prescription weight-loss tablets in the UK
Several weight-loss tablets are supplied through a prescription route. A provider checks the medicine, health information, current medicines and whether the route is appropriate before supplying it. A price comparison cannot replace that assessment, and a listed price is not a promise that a prescription will be issued.
Access also differs by medicine. Wegovy tablets are a private-prescription weight-management route. Mysimba is prescription only. Orlistat products can vary by strength and supply route, so the pack, pharmacy terms and any clinical checks need to be read before comparing cost.
Compare the main tablet routes or see current provider prices.